tert-butyl N-(2-oxoethyl)carbamate → HCID 67345340, compound

HRID 1669476Notes

Reaction equation

HRID 1669476 reaction equation
[CH:1]1([C:7]2[C:8]3[CH:9]=[CH:10][C:11]([C:35]([O:37][CH3:38])=[O:36])=[CH:12][C:13]=3[N:14]3[C:21]=2[C:20]2[CH:22]=[CH:23][CH:24]=[C:25]([CH2:26][N:27]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]4)[C:19]=2[O:18][CH2:17][C@H:16]([NH:33][CH3:34])[CH2:15]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O=[CH:40][CH2:41][NH:42][C:43](=[O:49])[O:44][C:45]([CH3:48])([CH3:47])[CH3:46]>>[C:45]([O:44][C:43]([NH:42][CH2:41][CH2:40][N:33]([CH3:34])[C@@H:16]1[CH2:15][N:14]2[C:13]3[CH:12]=[C:11]([C:35]([O:37][CH3:38])=[O:36])[CH:10]=[CH:9][C:8]=3[C:7]([CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)=[C:21]2[C:20]2[CH:22]=[CH:23][CH:24]=[C:25]([CH2:26][N:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[C:19]=2[O:18][CH2:17]1)=[O:49])([CH3:48])([CH3:47])[CH3:46]

Participants

3

Reactant 2

HCID 4247255tert-butyl N-(2-oxoethyl)carbamateHCID 67344394HCID 67344394, compound

Product 1

HCID 67345340HCID 67345340, compound

Procedure

The compound was prepared in analogy to Example 1, Step 6 from methyl (7R)-14-cyclohexyl-7-(methylamino)-4-(piperidin-1-ylmethyl)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate and tert-butyl (2-oxoethyl)carbamate. The compound was used without further purification. (ES+) m/z 659 (M+H)+.

Workup

  1. customThe compound was used without further purification

Sources & evidence

ORD record
ord-70ae19ce9e9446eea25cc6d02eeacd0f
Source dataset
uspto-grants-2011_08
Patent number
US07989438B2

Reaction notes

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