Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Methyl 4-bromobutyrate | HCID 107604 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 4-azidobutanoate | HCID 13202491 | — |
Reaction Steps
To a solution of methyl-4-bromobutyrate in DMSO (0.6 M) was added with stirring NaN3 (1.5 eq). The suspension was heated (45-50° C., oil bath) with stirring for 5 h. After cooling, H2O was added and the mixture extracted with Et2O. The organic extracts were washed with brine and dried over Na2SO4. The solvent was removed in vacuo and the crude oil used without further purification (99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07989438B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-922c7435902b486d99f0d73efd64851c |
|---|
| Source note | uspto-grants-2011_08 |
|---|
