3-(Methylamino)propanoic acid, N-BOC protected → HCID 67346185, compound

HRID 1669481Notes

Reaction equation

HRID 1669481 reaction equation
[CH:1]1([C:7]2[C:8]3[CH:9]=[CH:10][C:11]([C:32]([O:34][CH3:35])=[O:33])=[CH:12][C:13]=3[N:14]3[C:21]=2[C:20]2[CH:22]=[CH:23][CH:24]=[C:25]([O:26][CH3:27])[C:19]=2[O:18][CH2:17][C@H:16]([CH2:28][CH2:29][NH:30][CH3:31])[CH2:15]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:36]([O:40][C:41]([N:43]([CH3:49])[CH2:44][CH2:45][C:46]([OH:48])=O)=[O:42])([CH3:39])([CH3:38])[CH3:37]>>[C:36]([O:40][C:41]([N:43]([CH3:49])[CH2:44][CH2:45][C:46]([N:30]([CH3:31])[CH2:29][CH2:28][C@@H:16]1[CH2:15][N:14]2[C:13]3[CH:12]=[C:11]([C:32]([O:34][CH3:35])=[O:33])[CH:10]=[CH:9][C:8]=3[C:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)=[C:21]2[C:20]2[CH:22]=[CH:23][CH:24]=[C:25]([O:26][CH3:27])[C:19]=2[O:18][CH2:17]1)=[O:48])=[O:42])([CH3:37])([CH3:38])[CH3:39]

Participants

3

Reactant 2

HCID 27609523-(Methylamino)propanoic acid, N-BOC protectedHCID 67343600HCID 67343600, compound

Product 1

HCID 67346185HCID 67346185, compound

Procedure

The title compound was prepared in analogy to Example 13, Step 6 from methyl (7R)-14-cyclohexyl-4-methoxy-7-[2-(methylamino)ethyl]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate and N-(tert-butoxycarbonyl)-N-methyl-β-alanine

Sources & evidence

ORD record
ord-548b490d4eda4502b08ced10c7a7cda6
Source dataset
uspto-grants-2011_08
Patent number
US07989438B2

Reaction notes

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