Trifluoroacetic acid → HCID 67346138, compound

Participants

Reaction Conditions

Reaction Steps

TFA (>150 eq) and a few drops of water were added to a stirred solution of methyl 7-(3-tert-butoxy-3-oxopropyl)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (0.03 M) in DCM at RT. The reaction was heated at 60° C. (oil bath temp) for 1 h. Further TFA was introduced (circa 60 eq) and heating continued for 2 h. Volatiles were removed in vacuo. The residue was taken up in EtOAc and washed with 1N HCl (aq), brine before being dried (Na2SO4) filtered and concentrated in vacuo. Residual tert-BuOH was removed by sonication in Et2O/PE to afford the product (45%). (ES+) m/z 462 (M+H)+; 484 (M+Na)+.

Provenance & Evidence