HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1669485Generated: October 31, 2026
Diisopropylethylamine → HCID 67345211, compound
https://huagongshe.com/reaction/1669485
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67346138 | HCID 67346138 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67345211 | HCID 67345211 | — |
Reaction Steps
HATU (1.1 eq) was added to a stirred mixture of tert-butyl piperazine-1-carboxylate (1.1 eq), DIPEA (2.5 eq) and 3-[14-cyclohexyl-11-(methoxycarbonyl)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl]propanoic acid (0.03 M) in DMF under N2 at RT. The reaction was warmed at 50° C. for 10 min. The reaction was allowed to cool to RT before being partitioned between EtOAc and 1N HCl (aq). The organics were washed with 1N HCl (aq), sat. aq. NaHCO3, water and brine before being dried (Na2SO4), filtered and concentrated in vacuo. The material was taken on without further purification (88%). (ES+) m/z 630 (M+H)+; 652 (M+Na)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07989438B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-80687a583558449fbb2819592021d728 |
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| Source note | uspto-grants-2011_08 |
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