Tetrahydrofuran → HCID 67343811, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 14-cyclohexyl-7-(3-piperazin-1-ylpropyl)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (0.11 M) in dry THF was added (tert-butoxycarbonyl){[4-(dimethyliminio)pyridin-1(4H)-yl]sulfonyl}azanide (1 eq) (prepared following literature procedure: Winum, J.-Y. et al Org. Lett. 2001, 3, 2241-2243) and the mixture stirred at 40° C. for 2 h. The reaction was allowed to cool to RT before diluting with EtOAc. The combined organics were washed with 1N HCl (aq), sat. aq. NaHCO3 then brine, dried (Na2SO4), filtered and concentrated in vacuo to afford the product as a yellow foam (58%) that was used without further purification. (ES+) m/z 695 (M+H)+.

Provenance & Evidence