Sodium Hydroxide → HCID 67344080, compound

Participants

Reaction Conditions

Reaction Steps

2N NaOH (aq) (30 eq) was added to a solution of methyl 7-[3-(4-{[(tert-butoxycarbonyl)(methyl)amino]sulfonyl}piperazin-1-yl)propyl]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (0.06 M) in MeOH and the reaction stirred at 70° C. for 3 h. The reaction was allowed to cool to RT before reducing the volume of MeOH in vacuo. The residue was partitioned between 1N HCl (aq) and EtOAc, ensuring the aqueous phase was acidic. The aqueous was extracted a second time with EtOAc and the combined organics washed with brine before being dried (Na2SO4), filtered and concentrated in vacuo. The material was taken on without further purification. (ES+) m/z 681 (M+H)+.

Provenance & Evidence