HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1669496Generated: October 31, 2026
Water → 14-cyclohexyl-7-{[2-(methylamino)ethoxy]methyl}-N-{[methyl(2-oxoethyl)amino]sulfonyl}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide
https://huagongshe.com/reaction/1669496
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 14-cyclohexyl-N-{[(2,2-dimethoxyethyl)(methyl)amino]sulfonyl}-7-{[2-(methylamino)ethoxy]methyl}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide | HCID 86627911 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 14-cyclohexyl-7-{[2-(methylamino)ethoxy]methyl}-N-{[methyl(2-oxoethyl)amino]sulfonyl}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide | HCID 86627912 | — |
Reaction Steps
A solution of (7R or 7S)-14-cyclohexyl-N-{[(2,2-dimethoxyethyl)(methyl)amino]sulfonyl}-7-{[2-(methylamino)ethoxy]methyl}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide (0.05 M) in DCM was treated with an excess of TFA and H2O (>50 eq of each). The mixture was stirred at 40° C. for 40 min. The solution was allowed to cool to RT and used in the next step. (ES+) m/z 597 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07989438B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-843531ba282c4323b8a587514d11bc11 |
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| Source note | uspto-grants-2011_08 |
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