Sodium Hydroxide → HCID 67350881, compound

Participants

Reaction Steps

A solution of the product from step 6 (0.4 g, 0.72 mmol) and NaOH (62 mg, 1.54 mmol) in THF/water (1:1, 10 mL) was stirred at room temperature for 16 h. After the THF was removed, the aqueous solution was acidified with 10% HCl to pH=2, the solid was collected on a filter to yield the title compound (340 mg, 82%). 1HNMR (CDCl3) δ 1.42 (s, 9H), 3.15 (m, 2H), 4.57 (m, 1H), 5.00 (m, 1H), 6.95 (d, J=8.8 Hz, 2H), 7.02-7.15 (m, 6H), 7.17 (d, J=8.8 Hz, 2H), 7.30 (d, J=3.2 Hz, 1H), 7.85 (d, J=3.2 Hz, 1H), 7.91 (d, J=8.8 Hz, 2H).

Provenance & Evidence