Hydrochloric Acid → HCID 24815984, compound

Participants

Reaction Steps

To {(S)-2-[4-(4-chloro-phenoxy)-phenyl]-1-hydroxyaminomethyl-ethyl}-carbamic acid tert-butyl ester (18 mg, 0.046 mmol, 1 eq) in a 2 ml-vial was added 4 N HCl in dioxane (1 ml, 4 mmol, 86 eq.). The mixture was shaken at rt overnight. Then the volatile material was removed to give the desired product (10 mg, 74% yield) as white solid. 1H NMR (400 MHz, DMSO-d6) δ 2.94-3.01 (dd, J=6.8, 11.2 Hz, 1H), 3.01-3.05 (dd, J=5.2, 11.2 Hz, 1H), 3.17-3.20 (dd, J=2.4, 11.2 Hz, 1H), 3.37-3.42 (m, 1H), 3.80 (m, 1H), 7.02-7.05 (m, 4H), 7.34-7.35 (d, J=6.8 Hz, 2H), 7.43-7.45 (m, 2H); LCMS (UV, ESI), 294 (M+1), 87% purity.

Provenance & Evidence