Pyridine → HCID 86618212, compound

Participants

Reaction Steps

To a solution of {(S)-2-[4-(4-chloro-phenoxy)-phenyl]-1-hydroxyaminomethyl-ethyl}-carbamic acid tert-butyl ester (34 mg, 0.087 mmol, 1 eq.) in pyridine (2 ml) was added acetic anhydride (20 mg, 0.173 mmol, 2 eq.). And then the reaction mixture was stirred at room temperature for 1 hr. The reaction mixture was poured into sodium bicarbonate solution (25 ml) and extracted with ethyl acetate (3×15 ml). The combined organics was washed with 1N HCl (3×15 ml). After dried over anhydrous MgSO4, solvent was removed under reduced pressure to give a residue, which was purified by chromatography on silica gel using EA/hexane (1:2 to 1:1) as eluent to give the desired product (44 mg, 100% yield) as gummy.

Provenance & Evidence