Ammonium Chloride → HCID 86618213, compound

Participants

Reaction Steps

To a solution of {(S)-1-[(Acetoxy-acetyl-amino)-methyl]-2-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-carbamic acid tert butyl ester (27 mg, 0.057 mmol, 1 eq.) in MeOH (2 ml) was added sodium methoxide (15 mg, 0.27 mmol, 4.7 eq.) until pH=10. The mixture was stirred at room temperature for 30 min. Then was poured into saturated NH4Cl solution (15 ml). The mixture was extracted with dichloromethane (3×5 ml). The combined DCM layers were washed with sodium bicarbonate solution (5 ml) and dried over anhydrous MgSO4. Removal of solvent under reduced pressure gave the desired product (20 mg, 81% yield) as an oil.

Provenance & Evidence