Hydrochloric Acid → HCID 24815986, compound

Participants

Reaction Steps

To a 40 ml vial was charged with {(S)-1-[(Acetyl-hydroxy-amino)-methyl]-2-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-carbamic acid tert butyl ester (20 mg, 0.046 mmol, 1 eq.) followed by 4 N HCl (1 ml, 4 mmol, 86 eq.). The mixture was stirred at room temperature for 2 hr. The volatile material was removed under reduced pressure to give the desired product (20 mg, 100% yield) as white solid. 1H NMR (400 MHz, DMSO-d6) δ 2.02 (s, 3H), 2.83-2.87 (dd, J=6.4, 11.2 Hz, 1H), 3.17-3.20 (dd, J=4.8, 11.2 Hz, 1H), 3.46-3.87 (m, 4H), 7.0-7.03 (m, 4H), 7.32-7.33 (d, J=6.8 Hz, 2H), 7.42-7.44 (m, 2H), 8.06 (s, brs, 3H); LCMS (UV, ESI), 335 (M+1), 86% purity.

Provenance & Evidence