Dimethylformamide → HCID 67351851, compound

Participants

Reaction Steps

To a solution of 1-(2-Bromo-ethoxy)-4-phenoxy-benzene (2.5 g, 8.53 mmol), potassium carbonate (3.21 g, 23.3 mmol), and N,N-Dimethylformamide (150 mL) was added Boc-L-Tyrosine methyl ester (2.3 g, 7.75 mmol). The mixture was poured into 200 mL water solution and extracted with ethyl acetate (EtOAc) (3×100 mL). The combined organic layers were washed with brine (40 mL) and dried over anhydrous Na2SO4. The organic layer was concentrated in vacuo to obtain the crude mixture, which was purified by of silica gel flash chromatography, using EtOAc/hexane (gradient system), to obtain the product (2.54 g, 59%): 1H NMR (400 MHz, CDCL3).

Provenance & Evidence