反应详情

温度

80 °C

In a 50 ml three-necked flask, 5 g (44.6 mmol, 1 eq) of 2-ethylthiophene are dissolved in 28 ml of acetic anhydride, 0.5 ml of ortho-phosphoric acid are added and the reaction mixture is then heated for 1 hour at 80° C. The acids are evaporated off under reduced pressure, and the oil obtained is then filtered over a silica patch (eluent: 20% ethyl acetate, 80% heptane) after evaporation of the solvents: 5.2 g of 1-(5-ethylthiophen-2-yl)ethanone are obtained in the form of a brown oil. Yield: 76%.

1. customThe acids are evaporated off under reduced pressure
2. customthe oil obtained
3. filtrationis then filtered over a silica patch (eluent: 20% ethyl acetate, 80% heptane)
4. customafter evaporation of the solvents