Trifluoroacetic acid → N-(2-Aminoacetyl)-4-(2-butyl-4-chloro-5-formyl-imidazol-1-ylmethyl)benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	{2-[4-(2-Butyl-4-chloro-5-formylimidazol-1-ylmethyl)benzenesulfonylamino]-2-oxoethyl}carbamic acid t-butyl ester	HCID 57931394	—
Solvent	Dichloromethane	HCID 6344	—
Product	N-(2-Aminoacetyl)-4-(2-butyl-4-chloro-5-formyl-imidazol-1-ylmethyl)benzenesulfonamide	HCID 57931395	—

Reaction Steps

Intermediate (2d) (5.6 g) was dissolved into 20 mL 30% TFA:DCM and stirred at room temperature for 2 hours. The mixture was concentrated under reduced pressure to yield the title compound as an oil in a quantitative yield. MS m/z: [M+H+] calcd for C17H21ClN4O4S 413.1; found 413.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07989484B2
Source dataset	uspto-grants-2011_08
ORD ID	ord-516cea9c330e49faba204513c5f62c3a
Source note	uspto-grants-2011_08