N-[[18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-4-yl]carbonyl](cyclopropyl)sulfonamide → N-[18-[2-(thiazol-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carbonyl]-(cyclopropyl)sulfonamide

HRID 1669555Notes

Reaction equation

HRID 1669555 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:15]=[C:14]([O:16][CH:17]2[CH2:35][CH:34]3[N:19]([C:20](=[O:40])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH:27]=[CH:28][CH:29]4[C:31]([C:37]([OH:39])=O)([NH:32][C:33]3=[O:36])[CH2:30]4)[CH2:18]2)[C:13]2[C:8](=[C:9]([CH3:43])[C:10]([O:41][CH3:42])=[CH:11][CH:12]=2)[N:7]=1.C(C1N=C(C2C=C(OC3CC4N(C(=O)CCCCCCC=CC5C(C([NH:85][S:86]([CH:89]6[CH2:91][CH2:90]6)(=[O:88])=[O:87])=O)(NC4=O)C5)C3)C3C(=CC(OC)=CC=3)N=2)SC=1)(C)C>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:15]=[C:14]([O:16][CH:17]2[CH2:35][CH:34]3[N:19]([C:20](=[O:40])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH:27]=[CH:28][CH:29]4[C:31]([C:37]([NH:85][S:86]([CH:89]5[CH2:91][CH2:90]5)(=[O:88])=[O:87])=[O:39])([NH:32][C:33]3=[O:36])[CH2:30]4)[CH2:18]2)[C:13]2[C:8](=[C:9]([CH3:43])[C:10]([O:41][CH3:42])=[CH:11][CH:12]=2)[N:7]=1

Participants

3

Reactant 2

HCID 67318810N-[[18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-4-yl]carbonyl](cyclopropyl)sulfonamideHCID 6731979818-[2-(Thiazol-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid

Product 1

HCID 67319185N-[18-[2-(thiazol-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carbonyl]-(cyclopropyl)sulfonamide

Procedure

The title compound was prepared from 18-[2-(thiazol-2-yl)-7-methoxy-8-methyl-quinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid 25 following the procedure reported for synthesis of N-[[18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo-[14.3.0.04,6]nonadec-7-en-4-yl]carbonyl](cyclopropyl)sulfonamide 11: m/z=708 (M+H)+.

Sources & evidence

ORD record
ord-9c69aafd0c824ff991e00317d52a7554
Source dataset
uspto-grants-2011_08
Patent number
US07989471B2

Reaction notes

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