HRID1669556

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7047

Quinoline

C9H7N

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCCCC(=O)N4C3)cc(-c3nc(C(C)C)cs3)nc2c1

HCID67319685

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCCCC(=O)N4C3)cc(-c3nc(C(C)C)cs3)nc2c1C

HCID67318959

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from quinoline 28 and intermediate 7 following the procedure (Step F-H) reported for 18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid 10: m/z=647 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-af116f9f3f514c799f7685468b09854a
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07989471B2
来源说明: uspto-grants-2011_08

反应 SMILES

N1C2C(=CC=CC=2)C=C[CH:2]=1.[CH:11]([C:14]1[N:15]=[C:16]([C:19]2[CH:28]=[C:27]([O:29][CH:30]3[CH2:48][CH:47]4[N:32]([C:33](=[O:53])[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH:40]=[CH:41][CH:42]5[C:44]([C:50]([OH:52])=[O:51])([NH:45][C:46]4=[O:49])[CH2:43]5)[CH2:31]3)[C:26]3[C:21](=[CH:22][C:23]([O:54][CH3:55])=[CH:24][CH:25]=3)[N:20]=2)[S:17][CH:18]=1)([CH3:13])[CH3:12]>>[CH:11]([C:14]1[N:15]=[C:16]([C:19]2[CH:28]=[C:27]([O:29][CH:30]3[CH2:48][CH:47]4[N:32]([C:33](=[O:53])[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH:40]=[CH:41][CH:42]5[C:44]([C:50]([OH:52])=[O:51])([NH:45][C:46]4=[O:49])[CH2:43]5)[CH2:31]3)[C:26]3[C:21](=[C:22]([CH3:2])[C:23]([O:54][CH3:55])=[CH:24][CH:25]=3)[N:20]=2)[S:17][CH:18]=1)([CH3:13])[CH3:12]