Quinoline → 18-[2-(4-Isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid

HRID 1669556Notes

Reaction equation

HRID 1669556 reaction equation
N1C2C(=CC=CC=2)C=C[CH:2]=1.[CH:11]([C:14]1[N:15]=[C:16]([C:19]2[CH:28]=[C:27]([O:29][CH:30]3[CH2:48][CH:47]4[N:32]([C:33](=[O:53])[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH:40]=[CH:41][CH:42]5[C:44]([C:50]([OH:52])=[O:51])([NH:45][C:46]4=[O:49])[CH2:43]5)[CH2:31]3)[C:26]3[C:21](=[CH:22][C:23]([O:54][CH3:55])=[CH:24][CH:25]=3)[N:20]=2)[S:17][CH:18]=1)([CH3:13])[CH3:12]>>[CH:11]([C:14]1[N:15]=[C:16]([C:19]2[CH:28]=[C:27]([O:29][CH:30]3[CH2:48][CH:47]4[N:32]([C:33](=[O:53])[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH:40]=[CH:41][CH:42]5[C:44]([C:50]([OH:52])=[O:51])([NH:45][C:46]4=[O:49])[CH2:43]5)[CH2:31]3)[C:26]3[C:21](=[C:22]([CH3:2])[C:23]([O:54][CH3:55])=[CH:24][CH:25]=3)[N:20]=2)[S:17][CH:18]=1)([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 7047QuinolineHCID 6731968518-[2-[4-(Isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid

Product 1

HCID 6731895918-[2-(4-Isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid

Procedure

The title compound was prepared from quinoline 28 and intermediate 7 following the procedure (Step F-H) reported for 18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid 10: m/z=647 (M+H)+.

Sources & evidence

ORD record
ord-af116f9f3f514c799f7685468b09854a
Source dataset
uspto-grants-2011_08
Patent number
US07989471B2

Reaction notes

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