18-[2-[4-(Isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid → 18-[7-Methoxy-2-(thiazol-2-yl)quinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid

HRID 1669558Notes

Reaction equation

HRID 1669558 reaction equation
OC1C2C(=CC(OC)=CC=2)N=C(C2SC=CN=2)C=1.C([C:22]1[N:23]=[C:24]([C:27]2[CH:36]=[C:35]([O:37][CH:38]3[CH2:56][CH:55]4[N:40]([C:41](=[O:61])[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH:48]=[CH:49][CH:50]5[C:52]([C:58]([OH:60])=[O:59])([NH:53][C:54]4=[O:57])[CH2:51]5)[CH2:39]3)[C:34]3[C:29](=[CH:30][C:31]([O:62][CH3:63])=[CH:32][CH:33]=3)[N:28]=2)[S:25][CH:26]=1)(C)C>>[CH3:63][O:62][C:31]1[CH:30]=[C:29]2[C:34]([C:35]([O:37][CH:38]3[CH2:56][CH:55]4[N:40]([C:41](=[O:61])[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH:48]=[CH:49][CH:50]5[C:52]([C:58]([OH:60])=[O:59])([NH:53][C:54]4=[O:57])[CH2:51]5)[CH2:39]3)=[CH:36][C:27]([C:24]3[S:25][CH:26]=[CH:22][N:23]=3)=[N:28]2)=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 6731968518-[2-[4-(Isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acidHCID 178487699HCID 178487699, compound

Product 1

HCID 6732021718-[7-Methoxy-2-(thiazol-2-yl)quinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid

Procedure

The title compound was prepared from 4-hydroxy-7-methoxy-2-(thiazol-2-yl)quinoline and intermediate 7 following the procedure (Step F-H) reported for 18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid 10: m/z=591 (M+H)+.

Sources & evidence

ORD record
ord-8d2a2a572ded49148815950e090c5e37
Source dataset
uspto-grants-2011_08
Patent number
US07989471B2

Reaction notes

Loading…