18-[2-[4-(Isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid → HCID 67320290, compound

HRID 1669562Notes

Reaction equation

HRID 1669562 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([C:14]2[N:15]=[CH:16][S:17][CH:18]=2)[CH:3]=1.C(C1N=C(C2C=C(O[CH:38]3[CH2:56][CH:55]4[N:40]([C:41](=[O:61])[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH:48]=[CH:49][CH:50]5[C:52]([C:58]([OH:60])=[O:59])([NH:53][C:54]4=[O:57])[CH2:51]5)[CH2:39]3)C3C(=CC(OC)=CC=3)N=2)SC=1)(C)C>>[CH3:13][O:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([O:1][CH:38]3[CH2:56][CH:55]4[N:40]([C:41](=[O:61])[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH:48]=[CH:49][CH:50]5[C:52]([C:58]([OH:60])=[O:59])([NH:53][C:54]4=[O:57])[CH2:51]5)[CH2:39]3)=[CH:3][C:4]([C:14]3[N:15]=[CH:16][S:17][CH:18]=3)=[N:5]2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 6731968518-[2-[4-(Isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acidHCID 178487685HCID 178487685, compound

Product 1

HCID 67320290HCID 67320290, compound

Procedure

The title compound was prepared from 4-hydroxy-7-methoxy-2-(thiazol-4-yl)quinoline and intermediate 7 following the procedure (Step F-H) reported for 18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo-[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid 10: m/z=591 (M+H)+.

Sources & evidence

ORD record
ord-e783abbe4f4d464b861595c216053c27
Source dataset
uspto-grants-2011_08
Patent number
US07989471B2

Reaction notes

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