HRID1669581

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID145742

L-Proline

C5H9NO2

HCID543977

7-Octenoic acid

C8H14O2

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCCCC(=O)N4C3)cc(-c3nc(C(C)C)cs3)nc2c1

HCID67319685

未命名化合物

HCID178487691

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCCC(=O)N4C3)cc(-c3nc(C(C)C)cs3)nc2c1C

HCID67318953

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 4-hydroxy-2-(4-isopropylthiazol-2-yl)-7-methoxyquinoline, oct-7-enoic acid and intermediate 5 following the procedure (Step D-H) reported for 18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid 10: m/z=619 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-44aa49b3148b4e28a99f8ff585c687ab
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07989471B2
来源说明: uspto-grants-2011_08

反应 SMILES

O[C:2]1C2C(=CC(OC)=CC=2)N=C(C2SC=C(C(C)C)N=2)C=1.C(O)(=O)CCCCCC=C.N1CCC[C@H]1C(O)=O.[CH:40]([C:43]1[N:44]=[C:45]([C:48]2[CH:57]=[C:56]([O:58][CH:59]3[CH2:77][CH:76]4[N:61]([C:62](=[O:82])C[CH2:64][CH2:65][CH2:66][CH2:67][CH2:68][CH:69]=[CH:70][CH:71]5[C:73]([C:79]([OH:81])=[O:80])([NH:74][C:75]4=[O:78])[CH2:72]5)[CH2:60]3)[C:55]3[C:50](=[CH:51][C:52]([O:83][CH3:84])=[CH:53][CH:54]=3)[N:49]=2)[S:46][CH:47]=1)([CH3:42])[CH3:41]>>[CH:40]([C:43]1[N:44]=[C:45]([C:48]2[CH:57]=[C:56]([O:58][CH:59]3[CH2:77][CH:76]4[N:61]([C:62](=[O:82])[CH2:64][CH2:65][CH2:66][CH2:67][CH2:68][CH:69]=[CH:70][CH:71]5[C:73]([C:79]([OH:81])=[O:80])([NH:74][C:75]4=[O:78])[CH2:72]5)[CH2:60]3)[C:55]3[C:50](=[C:51]([CH3:2])[C:52]([O:83][CH3:84])=[CH:53][CH:54]=3)[N:49]=2)[S:46][CH:47]=1)([CH3:42])[CH3:41]