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HRID1669582

反应详情

EQUATION

反应方程式

HRID 1669582 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCCCC(=O)N4C3)cc(-c3nc(C(C)C)cs3)nc2c1
HCID67318810

未命名化合物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCCC(=O)N4C3)cc(-c3nc(C(C)C)cs3)nc2c1C
HCID67318953

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCCC(=O)N4C3)cc(-c3nc(C(C)C)cs3)nc2c1
HCID67317849

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 17-[2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-2,14-dioxo-3,15-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (62) following the procedure reported for synthesis of N-[[18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo-[14.3.0.04,6]nonadec-7-en-4-yl]carbonyl](cyclopropyl)sulfonamide 11: m/z=722 (M+H)+. 1H NMR (CDCl3): 0.99-1.77 (m, 17H), 1.94 (dd, J=6.0 Hz, J=9.7 Hz, 1H), 2.12-2.26 (m, 2H), 2.37 (dd, J=7.3 Hz, 16.4 Hz, 1H), 2.57-2.71 (m, 3H), 2.96 (m, 1H), 3.04 (m, 1H), 3.22 (m, 1H), 3.92 (m, 1H), 3.96 (s, 3H), 4.14 (dd, J=3.7 Hz, 11.3 Hz, 1H), 4.58 (t, J=7.9 Hz, 1H), 5.05 (t, J=10.6 Hz, 1H), 5.53 (m, 1H), 5.66 (m, 1H), 6.58 (s, 1H), 7.06 (s, 1H), 7.12 (dd, J=2.5 Hz, J=9.1 Hz, 1H), 7.37 (d, J=2.5 Hz, 1H), 7.56 (s, 1H), 7.93 (d, J=9.1 Hz, 1H), 10.8 (br s, 1H).