HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1669651Generated: November 1, 2026
2-Nitrophenol → 1-(2-chloroethoxy)-2-nitrobenzene
https://huagongshe.com/reaction/1669651
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Nitrophenol | HCID 6947 | — |
| Reactant | 1-Bromo-2-Chloroethane | HCID 7849 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-chloroethoxy)-2-nitrobenzene | HCID 4362487 | — |
Reaction Steps
A suspension of 2-nitrophenol (50.0 g, 0.36 mol), 1-bromo-2-chloroethane (45 mL, 0.54 mol), and K2CO3 (100.0 g, 0.72 mol) in DMF (200 mL) was stirred at 90° C. for 2 h, cooled to room temperature, poured into ice-water, filtered, washed with H2O and dried to give Compound 7, 70.3 g (96%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07989617B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-48a3c9d7769b4e96b07c47fdfed2a858 |
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| Source note | uspto-grants-2011_08 |
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