Pyrimidine, 5-bromo-2-methoxy- → (5S)-5-({[4-[(2-Methoxypyrimidin-5-yl)ethynyl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl}methyl)-5-methylimidazolidine-2,4-dione

HRID 1669666Notes

Reaction equation

HRID 1669666 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[C:10]([C:12]1[CH2:13][CH2:14][N:15]([S:18]([CH2:21][C@@:22]2([CH3:29])[NH:26][C:25](=[O:27])[NH:24][C:23]2=[O:28])(=[O:20])=[O:19])[CH2:16][CH:17]=1)#[CH:11]>>[CH3:9][O:8][C:5]1[N:4]=[CH:3][C:2]([C:11]#[C:10][C:12]2[CH2:17][CH2:16][N:15]([S:18]([CH2:21][C@@:22]3([CH3:29])[NH:26][C:25](=[O:27])[NH:24][C:23]3=[O:28])(=[O:20])=[O:19])[CH2:14][CH:13]=2)=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 139657Pyrimidine, 5-bromo-2-methoxy-HCID 86642354(5S)-5-{[(4-Ethynyl-3,6-dihydropyridin-1(2H)-yl)sulfonyl]methyl}-5-methylimidazolidine-2,4-dione

Product 1

HCID 11553220(5S)-5-({[4-[(2-Methoxypyrimidin-5-yl)ethynyl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl}methyl)-5-methylimidazolidine-2,4-dione

Procedure

The title compound was prepared from 5-bromo-2-methoxypyrimidine and (5S) -5-{[(4-ethynyl-3,6-dihydropyridin-1(2H)-yl)sulfonyl]methyl}-5-methylimidazolidine-2,4-dione in the same way as described in Example 1.

Sources & evidence

ORD record
ord-d308d45945344a64b5a780e89407df21
Source dataset
uspto-grants-2011_08
Patent number
US07989620B2

Reaction notes

Loading…