1,2-Dichloroethane → HCID 11603382, compound

Participants

Reaction Steps

A mixture of 3-phenylpropionic acid (20 mg, 0.13 mmol), (+)-5-amino-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one (30 mg, 0.12 mmol, described in Intermediate 5), EDC (25 mg, 0.13 mmol), HOBT (20 mg, 0.13 mmol), and N,N-diisopropylethylamine (0.023 mmol) was stirred in DMF (0.5 mL) at ambient temperature for 3 h. The crude mixture was purified directly by HPLC using a reversed phase C18 column and eluting with a gradient of H2O:CH3CN:CF3CO2H-90:10:0.1 to 5:95:0.1. Lyophilization provided the title compound. MS: m/z=384 (M+1). HRMS: m/z=384.1725; calculated m/z=384.1707 for C24H22N3O2.

Provenance & Evidence