2-Methoxybenzylamine → HCID 67334113, compound

Participants

Reaction Steps

5-Nitro-2-chloroquinoline (CAS 13067-94-2,3 g, 14 mmol) and 2-methoxy-benzylamine (4.2 g, 31 mmol) were stirred in a sealed tube at 120° C. overnight. The reaction mixture was purified by flash chromatography on silica gel (heptane/ethyl acetate 100:0->30:70 gradient). (2-Methoxy-benzyl)-(5-nitro-quinolin-2-yl)-amine was obtained as a yellow solid (2.2 g, 50%), MS: m/e=310.1 (M+H+).

Provenance & Evidence