反应详情

5-Bromo-2-chloroquinoline (CAS 99455, 2.2 g, 9 mmol) and 5-methyl-2-furanmethanamine (2.2 g, 20 mmol) were stirred in a sealed tube at 120° C. overnight. The reaction mixture was purified by flash chromatography on silica gel (heptane/ethyl acetate 100:0->80:20 gradient). (5-Bromo-quinolin-2-yl)-(5-methyl-furan-2-ylmethyl)-amine was obtained as a light brown solid (2.67 g, 92%), MS: m/e =317.1 and 319.0 (M+H+).

1. customThe reaction mixture was purified by flash chromatography on silica gel (heptane/ethyl acetate 100:0->80:20 gradient)