Dimethylsulphamoyl chloride → N,N-dimethyl-N'-{2-[(2-methyl-2,3-dihydro-1-benzofuran-7-yl)amino]quinolin-5-yl}sulfamide

HRID 1669715Notes

Reaction equation

[CH3:1][CH:2]1[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([NH:11][C:12]3[CH:21]=[CH:20][C:19]4[C:18]([NH2:22])=[CH:17][CH:16]=[CH:15][C:14]=4[N:13]=3)[C:4]=2[O:3]1.[CH3:23][N:24]([CH3:29])[S:25](Cl)(=[O:27])=[O:26]>>[CH3:23][N:24]([CH3:29])[S:25]([NH:22][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]=1[CH:20]=[CH:21][C:12]([NH:11][C:10]1[C:4]3[O:3][CH:2]([CH3:1])[CH2:6][C:5]=3[CH:7]=[CH:8][CH:9]=1)=[N:13]2)(=[O:27])=[O:26]

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 44217992N2-(2-Methyl-2,3-dihydro-benzofuran-7-yl)-quinoline-2,5-diamine

Product 1

HCID 44218314N,N-dimethyl-N'-{2-[(2-methyl-2,3-dihydro-1-benzofuran-7-yl)amino]quinolin-5-yl}sulfamide

Procedure

The title compound, MS: m/e=399.1 (M+H+), was prepared in accordance with the general method of example 19 from N2-(2-methyl-2,3-dihydro-benzofuran-7-yl)-quinoline-2,5-diamine and dimethylsulfamoyl chloride.

Sources & evidence

ORD record: ord-9f34bde6c5ba4be4af4fdf0e1deb00e1
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989628B2

Reaction notes

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