HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1067642-12-9 | HCID 25130137 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanamide | HCID 25129795 | 37% |
Reaction Steps
Slow hydrolysis of the alkylation product (compound 1) with KOH in t-BuOH at 100° C. for 2-3 days gave the required precursor (4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylbutanamide; compound 2 in the scheme above) in about 37% yield. Intermediate nitrile and amide precursor were characterized by spectroscopic techniques including 1H and 13C NMR, and LC-MS.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989630B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-037f44da8c724701bd0fa09c81c471b5 |
| Source note | uspto-grants-2011_08 |