2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → Ethyl 5-acetyl-2,6-dimethyl-4-(5-fluoro-2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydropyridine-3-carboxylate

Participants

Reaction Steps

150 mg (0.52 mmol) of 3-[(5-fluoro-2-methyl-4-oxo-4H-chromen-8-yl)methylene]pentane-2,4-dione are dissolved with 33.6 mg (0.26 mmol) of ethyl 3-aminocrotonate in 5 ml of 2-propanol and heated under reflux under argon for 3 h. The solvent is removed in vacuo, and the residue is purified by column chromatography (mobile phase: ethyl acetate/cyclohexane 2:1). 50.1 mg (48% of theory) of the title compound are obtained as a yellow solid.

Provenance & Evidence