反应详情

353 mg (1.06 mmol) of 2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]-1-phenylbutane-1,3-dione are dissolved with 137 mg (1.06 mmol) of ethyl 3-aminocrotonate in 5 ml of ethanol and heated under reflux under argon for 24 h. The reaction solution is purified by preparative HPLC. Concentration of the product fractions and crystallization from ethyl acetate result in 245 mg (52% of theory) of the title compound as a yellow solid.

1. temperatureheated
2. temperatureunder reflux under argon for 24 h
3. customThe reaction solution is purified by preparative HPLC
4. customConcentration of the product fractions and crystallization from ethyl acetate