Acetic Acid → HCID 67343678, compound

Participants

Reaction Steps

A solution of 200 mg (1.06 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde in 20 ml of dichloromethane is mixed with 229.73 mg (1.06 mmol) of 4,4,4-trifluoro-1-phenyl-1,3-butanedione, 0.08 ml (1.33 mmol) of acetic acid and 0.01 ml (0.11 mmol) of piperidine and stirred under reflux with a water trap overnight. After cooling, the mixture is diluted with dichloromethane and washed with saturated sodium chloride solution. The organic phase is dried over sodium sulfate and concentrated. 474 mg (>100% of theory) of the desired product are obtained as a yellow oil which is reacted further without purification.

Provenance & Evidence