2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → HCID 16045281, compound

Participants

Reaction Steps

A solution of 410 mg (1.06 mmol) of 4,4,4-trifluoro-2-[(2-methyl-4-oxo-4H-chromen-8-yl)-methylene]-1-phenylbutane-1,3-dione in 10 ml of 2-propanol is mixed with 137.3 mg (1.06 mmol) of ethyl 3-aminocrotonate and stirred under reflux for 12 h. After cooling, the reaction mixture is concentrated, and the residue is taken up in 5 ml of acetic acid and again stirred under reflux for 12 h. The reaction solution is concentrated and the residue is purified by preparative HPLC. 160.3 mg (30.3% of theory) of the title compound are obtained.

Provenance & Evidence