Acetic Acid → 1-(4-Methoxyphenyl)-2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]butane-1,3-dione

Participants

Reaction Steps

250 mg (1.32 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 281 mg (1.46 mmol) of 1-(4-methoxyphenyl)butane-1,3-dione, 100 mg (1.66 mmol) of acetic acid and 11 mg (0.13 mmol) of piperidine in 5 ml of dichloromethane and, after addition of molecular sieves, heated under reflux under argon for 4 h. The solvent is removed after filtration in vacuo. 480 mg (99% of theory) of the title compound are obtained and are employed without further purification in the next stage.

Provenance & Evidence