反应详情

960 mg (2.82 mmol) of cyclobutylmethyl 2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]-3-oxobutanoate are dissolved with 279 mg (2.82 mmol) of 4-aminopent-3-en-2-one in 10 ml of ethanol and heated under reflux under argon for 24 h. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. Concentration of the product fractions and crystallization from ethyl acetate result in 532 mg (44% of theory) of the title compound as a white solid.

1. temperatureheated
2. temperatureunder reflux under argon for 24 h
3. customThe solvent is removed in vacuo
4. customthe residue is purified by preparative HPLC
5. customConcentration of the product fractions and crystallization from ethyl acetate