Acetic Acid → HCID 76539464, compound

Participants

Reaction Steps

2.4 g (12 mmol) of 2,2,2-trifluoro-1-methylethyl 3-oxobutanoate are heated with 1.8 g (24.6 mmol) of ammonium acetate and 0.6 g (11 mmol) of acetic acid with the addition of molecular sieves at 110° C. for 5 h. After cooling to room temperature, the reaction mixture is mixed with water and extracted with ethyl acetate. Washing of the organic phase with water and saturated sodium chloride solution is followed by drying over magnesium sulfate. After filtration, the solvent is removed in vacuo. The resulting crude product (1.5 g, 77% purity, 77% of theory) is employed without further purification in the next stage.

Provenance & Evidence