Acetic Acid → HCID 57503359, compound

Participants

Reaction Steps

210 mg (1.11 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 145 mg (1.11 mmol) of ethyl 3-oxobutanoate, 200 mg (1.11 mmol) of 3-amino-1-(4-fluorophenyl)but-2-en-1-one and 6 μl (0.11 mmol) of acetic acid in 10 ml of 2-propanol and heated under reflux under argon for 30 h. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 172 mg (33% of theory) of the title compound are obtained as a yellow solid.

Provenance & Evidence