Acetic Acid → HCID 57503360, compound

Participants

Reaction Steps

110 mg (0.54 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 78 mg (0.54 mmol) of n-propyl 3-oxobutanoate, 97 mg (0.54 mmol) of 3-amino-1-(4-fluorophenyl)but-2-en-1-one and 6 μl (0.05 mmol) of acetic acid in 10 ml of 2-propanol and heated under reflux under argon for 30 h. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 228 mg (87% of theory) of the title compound are obtained as a yellow solid.

Provenance & Evidence