Acetic Acid → HCID 57503361, compound

Participants

Reaction Steps

164 mg (0.87 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 113 mg (0.87 mmol) of ethyl 3-oxobutanoate, 200 mg (0.87 mmol) of 3-amino-1-[4-(trifluoromethyl)phenyl]but-2-en-1-one and 5 μl (0.087 mmol) of acetic acid in 8 ml of 2-propanol and heated under reflux under argon for 30 h. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 59 mg (13% of theory) of the title compound are obtained as a yellow solid.

Provenance & Evidence