Acetic Acid → HCID 57503365, compound

Participants

Reaction Steps

100 mg (0.53 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 93.1 mg (0.93 mmol) of 2,4-pentanedione, 97 mg (0.53 mmol) of 2,2,2-trifluoroethyl 3-aminobut-2-enoate and 32 μl (0.55 mmol) of acetic acid in 5 ml of isopropanol and heated under reflux under argon for 10 h. The solvent is then removed in vacuo, and the residue is purified by column chromatography on silica gel (mobile phase: dichloromethane/methanol 95:5). 28 mg (12% of theory) of the title compound are obtained as a yellow solid.

Provenance & Evidence