化工社化工社 化学情報印刷レポート · 研究参考用
1H-1,2,4-Triazole → Anastrozole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1H-1,2,4-Triazole | HCID 9257 | — |
| 反応物 | 2,2'-(5-Bromomethyl-1,3-phenylene)di(2-methylpropiononitrile) | HCID 11522359 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 生成物 | Anastrozole | HCID 2187 | — |
反応手順
In yet another embodiment of the present invention, the purified bromo compound (formula (III)) is alkylated with 1,2,4-triazole in a suitable solvent using a suitable base in the presence of a phase transfer catalyst such as tetrabutyl ammonium bromide to obtain anastrozole, which is further purified using column chromatography, followed by precipitation/crystallization using ethyl acetate and diisopropyl ether to obtain pure anastrozole in high yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07989636B2 |
| 出典データセット | uspto-grants-2011_08 |
| ORD ID | ord-f88e4f2f632742f4a2220759f70d17bc |
| 出典メモ | uspto-grants-2011_08 |