Water → HCID 67335173, compound

Participants

Reaction Steps

To a warm solution of 0.45 g 4-({1-cyclohexyl-5-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-3-yl}methyl)benzonitrile from Step D above in 10 mL ethanol and 2.5 mL water was added 0.70 g potassium hydroxide pellets. The resulting solution was refluxed under nitrogen over night. Ethanol was removed under reduced pressure. The product was precipitated by adding 11.5 mL 1 N HCl to the residue. The title compound was collected by filtrated, washed with water several times, and dried to give a slightly yellowish solid. 1H NMR (CD3OD, 500 MHz) δ 7.94˜7.96 (m, 2H), 7.47˜7.49 (m, 2H), 7.37˜7.41 (m, 4H), 6.09 (s, 1H), 4.06 (s, 2H), 4.05 (tt, J=3.8 & 11.9 Hz, 1H), 1.97˜2.05 (m, 2H), 1.85˜1.93 (m, 4H), 1.67˜1.71 (m, 1H), 1.26˜1.36 (m, 3H). LC-MS: 2.38 min. (M+H=445.2).

Provenance & Evidence