HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 178522660, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 67335173 | HCID 67335173 | — |
| Reactant | HCID 178509300 | HCID 178509300 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178522660 | HCID 178522660 | — |
Reaction Steps
A solution of 55.6 mg product from Step E above, 28.8 mg EDC, 20.3 mg HOBt in 1 mL DMF was stirred at room temperature for 45 minutes. 5-Aminotetrazole monohydrate (15.5 mg) was added and the mixture stirred for additional 22 hours. DIEA (26 μL) and more EDC (13.8 mg) were added and the reaction continued for another day. The title compound was isolated on preparative HPLC using 75˜90% MeCN gradient over 10 minutes at 8.0 mL per minute with 0.1% TFA as a white solid following lyophilization. LC-MS: 2.26 min. (M+H=512.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989475B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-3d11aa0b2803490ab33a5dd611c999ec |
| Source note | uspto-grants-2011_08 |