1-(Pyrazin-2-yl)ethanamine → HCID 57770696, compound

HRID 1669887Notes

Reaction equation

HRID 1669887 reaction equation
[CH:1]([C:4]1[N:8]([C:9]2[CH:10]=[C:11]([C:22]([OH:24])=O)[CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=3)[CH:14]=2)[N:7]=[CH:6][N:5]=1)([CH3:3])[CH3:2].[N:25]1[CH:30]=[CH:29][N:28]=[CH:27][C:26]=1[CH:31]([NH2:33])[CH3:32]>>[N:25]1[CH:30]=[CH:29][N:28]=[CH:27][C:26]=1[CH:31]([NH:33][C:22]([C:11]1[CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[CH:14]=[C:9]([N:8]2[C:4]([CH:1]([CH3:2])[CH3:3])=[N:5][CH:6]=[N:7]2)[CH:10]=1)=[O:24])[CH3:32]

Participants

3

Reactant 2

HCID 185190061-(Pyrazin-2-yl)ethanamineHCID 57770871HCID 57770871, compound

Product 1

HCID 57770696HCID 57770696, compound

Procedure

5-(5-Isopropyl-[1,2,4]triazol-1-yl)-4′-methyl-biphenyl-3-carboxylic acid was subject to the amide coupling reaction described in step 4 of Example 6, but replacing 2-amino-propan-1-ol with 1-pyrazin-2-yl-ethylamine, to give 5-(5-isopropyl-[1,2,4]triazol-1-yl)-4′-methyl-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide, MS (M+H)=427.

Sources & evidence

ORD record
ord-5228695e314d456680aa998b50d7a86e
Source dataset
uspto-grants-2011_08
Patent number
US07989637B2

Reaction notes

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