1-(Pyrazin-2-yl)ethanamine → HCID 57770797, compound

HRID 1669890Notes

Reaction equation

HRID 1669890 reaction equation
[CH3:1][O:2][CH:3]([C:5]1[N:9]([C:10]2[CH:11]=[C:12]([C:23]([OH:25])=O)[CH:13]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)[CH:15]=2)[N:8]=[CH:7][N:6]=1)[CH3:4].[N:26]1[CH:31]=[CH:30][N:29]=[CH:28][C:27]=1[CH:32]([NH2:34])[CH3:33]>>[N:26]1[CH:31]=[CH:30][N:29]=[CH:28][C:27]=1[CH:32]([NH:34][C:23]([C:12]1[CH:13]=[C:14]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[CH:15]=[C:10]([N:9]2[C:5]([CH:3]([O:2][CH3:1])[CH3:4])=[N:6][CH:7]=[N:8]2)[CH:11]=1)=[O:25])[CH3:33]

Participants

3

Reactant 2

HCID 185190061-(Pyrazin-2-yl)ethanamineHCID 57770853HCID 57770853, compound

Product 1

HCID 57770797HCID 57770797, compound

Procedure

5-[5-(1-Methoxy-ethyl)-[1,2,4]triazol-1-yl]-4′-methyl-biphenyl-3-carboxylic acid was subject to the amide coupling reaction described in step 4 of Example 6, but replacing 2-amino-propan-1-ol with 1-pyrazin-2-yl-ethylamine, to give 5-[5-(1-methoxy-ethyl)-[1,2,4]triazol-1-yl]-4′-methyl-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide, MS (M+H)=443.

Sources & evidence

ORD record
ord-77afd47a97b84f2a81c4829dce371080
Source dataset
uspto-grants-2011_08
Patent number
US07989637B2

Reaction notes

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