Carbon Dioxide → HCID 57770742, compound

HRID 1669893Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[C:6]([N:17]2[C:21]([CH:22]([CH3:24])[CH3:23])=[C:20](C(O)=O)[N:19]=[N:18]2)[CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[CH:9]=1)([OH:3])=[O:2].C(=O)=O>>[CH:22]([C:21]1[N:17]([C:6]2[CH:5]=[C:4]([C:1]([OH:3])=[O:2])[CH:9]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=3)[CH:7]=2)[N:18]=[N:19][CH:20]=1)([CH3:24])[CH3:23]

Participants

Reactant 2

HCID 280Carbon Dioxide

HCID 57770868HCID 57770868, compound

Product 1

HCID 57770742HCID 57770742, compound

Procedure

The 1-(5-carboxy-4′-methyl-biphenyl-3-yl)-5-isopropyl-1H-[1,2,3]triazole-4-carboxylic acid from step 2 was heated to 170° C. until no further carbon dioxide was released. The reaction mixture was cooled to room temperature, and the resulting crude 5-(5-Isopropyl-[1,2,3]triazol-1-yl)-4′-methyl-biphenyl-3-carboxylic acid was used directly in the next step without further purification.

Workup

customthe resulting crude 5-(5-Isopropyl-[1,2,3]triazol-1-yl)-4′-methyl-biphenyl-3-carboxylic acid was used directly in the next step without further purification

Sources & evidence

ORD record: ord-679f42e7fc9c48c8938b40ca8bd3557c
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989637B2

Reaction notes

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