HCID 10867840, compound → HCID 10880397, compound

Participants

Reaction Steps

The N-Boc acid 2 (767 mg, 3.46 mmol) in 10 mL of dry CH2Cl2 was stirred overnight with 3 eq of tert-butyl-2,2,2-tricholoracetimdate (2.27 g). After concentration under reduced pressure, the crude product was purified by silica gel column chromatography (5% EtOAc in hexane) to provide 3 (510 mg, 53%) as a white solid: mp 41-42 EC (EtOAc/hexane); 1H NMR (CDCl3) δ 1.44 (9H, s), 1.47 (3H, d, J=2.4), 1.48 (9H, s), 4.57-4.85 (2H, m), 5.34 (1H, broad s). Anal. (C13H24FNO4) C, H, N.

Provenance & Evidence