Benzyl Chloride → 3-(Benzyloxy)-2,2-dimethylpropanoic acid

HRID 1670004Notes

Reaction equation

[CH3:1][C:2]([CH3:9])([CH2:6][O:7][CH3:8])[C:3]([OH:5])=[O:4].C(OC(=O)C(C)(C)CO)C.C(Cl)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:1][C:2]([CH3:9])([CH2:6][O:7][CH2:8][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:3]([OH:5])=[O:4]

Participants

Reactant 3

HCID 7503Benzyl Chloride

HCID 274432ethyl 3-hydroxy-2,2-dimethylpropanoate

HCID 30175063-Methoxy-2,2-dimethylpropanoic acid

Product 1

HCID 134782883-(Benzyloxy)-2,2-dimethylpropanoic acid

Procedure

The title compound was prepared following the procedure described in Intermediate 68 using 2,2-dimethyl-3-hydroxypropionic acid ethyl ester and benzyl chloride.

Sources & evidence

ORD record: ord-637b36843ba74f19af035bd6ec3427df
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989634B2

Reaction notes

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