Acetyl chloride → (2R)-2-methyl-3-acetyloxypropionic acid

Participants

Reaction Steps

To a solution of (2R)-2-methyl-3-hydroxypropionic acid (10.0 g, 100 mmol) in pyridine (30 mL) as added acetyl chloride(11.8 g, 15.0 mmol) at 0° C., and the reaction mixture was warmed to rt. After being stirried for 3 h, the reaction mixture was quenched with 1N HCl (30 mL), and the pH of the solution was adjusted to 3-4. The organic material was extracted with EtOAc, and the extracts were washed with 1N HCl at 4-5 times, dried over MgSO4, filtered, and concentrated to give the title compound (11.4 g, 95.0%).

Provenance & Evidence