HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-1-Cbz-3-[cyclohexyl(acetyloxypivaloyl)amino]pyrrolidine → (3S)-3-[cyclohexyl(acetyloxypivaloyl)amino]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-1-Cbz-3-[cyclohexyl(acetyloxypivaloyl)amino]pyrrolidine | HCID 67345539 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3S)-3-[cyclohexyl(acetyloxypivaloyl)amino]pyrrolidine | HCID 67343099 | 94.1% |
Reaction Steps
To a solution of (3S)-1-Cbz-3-[cyclohexyl (acetyloxypivaloyl)amino]pyrrolidine (1.00 g, 2.25 mmol), prepared in Step B, in dioxane (10 mL) was added portionwise Pd/C (200 mg), and the mixture was stirred for 12 h under hydrogen. The reaction solution was filtered though Celite and the filtratae concentrated to give the title compound (657 mg, 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989634B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-84864d1d48e64c3887e160a45429e41c |
| Source note | uspto-grants-2011_08 |